Study summary
Field evaluation of the efficacy and persistence of insect repellents DEET, IR3535, and KBR 3023 against Anopheles gambiae complex and other Afrotropical vector mosquitoes
Costantini C, Badolo A, Ilboudo-Sanogo E
- Study type
- Field Trial
- Year
- 2004
- Published in
- Transactions of the Royal Society of Tropical Medicine and Hygiene 98(11):644-652
- Evidence strength
- Definitive evidence
Summary
Large topical field trial in Burkina Faso directly comparing skin-applied DEET, IR3535, and KBR 3023 (picaridin) against wild malaria vectors, with over 49,000 mosquitoes collected (~95% Anopheles gambiae complex).
Key findings
After 10 h, picaridin gave the highest protection against anophelines, then DEET, then IR3535. ED95 (ug/cm2): DEET 94.3, IR3535 212.4, picaridin 81.8; skin half-lives: DEET 2.9 h, IR3535 2.9 h, picaridin 4.1 h. IR3535 required higher doses but still provided substantial topical protection.
Limitations
Single region (West Africa); efficacy ranking is dose-dependent; focuses on anophelines.